Aristizabal-Pachon et al., for the first time, showed a significant association between AXIN2 rs151279728 and rs2240308 polymorphisms and breast cancer susceptibility in a Brazilian population, which indicating the role of Wnt/β-catenin pathway dysfunction in breast cancer tumorigenesis (Aristizabal-Pachon et al, 2015). This evidence concerns the gene AXIN2 and breast cancer.