AXIN2 and cancer: Axis inhibition protein 2 (AXIN2) also known as axin-like protein (Axil), a key component of the Wnt signaling pathway, plays an important role in the regulation of cell proliferation, cytometaplasia, migration, apoptosis and other important cellular functions, and it has demonstrated a close relationship with the development of some cancers (Xu et al., 2020).