In accordance with these findings, several studies have demonstrated the growth inhibitory effects SIL in rat models of urinary bladder cancer, associated with elevated levels of p53 expression, phosphorylation of ERK1/2 and phospho-p65, as well as downregulation of survivin, cyclin D1 (Barros et al., 2020). This evidence concerns the gene MAPK3 and urinary bladder cancer.