When TM levels in patients with adenocarcinoma and squamous variants of NSCLC were compared, the median values of CEA, CYFRA 21-1, NSE, and ProGRP were higher among patients with adenocarcinoma, and median value of SCC was higher among patients with squamous NSCLC; statistical significance was found with CEA, NSE, and SCC (Table 2). This evidence concerns the gene ENO2 and adenocarcinoma.