TNF and neoplasm: As shown in Fig. 4D, the expression levels of IL-1, IL-6, IL-10 and TNF-α were up-regulated in the treatment group, which suggested that the up-regulated expression of IL and TNF-α may inhibit invasion and angiogenesis(Figure 4D).Taken together, these results indicated that Rh2 may inhibit proliferation, promote apoptosis and down-regulate the expression of genes associated with tumor angiogenesis in HepG2 cells.