Some studies showed that cytochromes P450 activated 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine, the most abundant heterocyclic amine in cooked meat, beer and cigarette, further metabolized by NAT enzymes, which in turn results to the increased mutation frequency and tumor incidence (Bendaly et al., 2009). This evidence concerns the gene BRD2 and neoplasm.