TGFB1 and breast carcinoma: Although the combination of Tranilast and tamoxifen has also decreased the expression levels of TGFβ1, TGF-β2, TGF-β3 TGFβ-RI, and TGFβ-RII, it increased the level of TGFβ-RIII in breast cancer cells (MCF-7) (Darakhshan and Ghanbari, 2013).