MAPK3 and Familial prostate cancer: On the other hand, Tranilast decreases growth and differentiation of some cancerous cells, including prostate cancer cells (CU 145, PC3, (LNcap) (Murahashi et al., 1998) by increasing phosphorylation of AKT1 and decreasing the phosphorylation of ERK1 / 2 as well as G1/S cell cycle arrest in murine breast cancer cell line (Subramaniam et al., 2010).