(Octamer 4) OCT4, NANOG, (SRY-related HMG-box gene 2) SOX2 KLF4 (Krupel-like factor4) genes are transcription factors that control the differentiation and design of embryonic stem cells; however, recent studies have indicated that the expression of these genes is involved in the development of many cancers, including the bladder, liver, breast, and colorectal cancer, pvalue is (P<0.05) (Gillis et al., 2011; Ibrahim et al., 2012; Yin et al., 2013; Nagata et al., 2014; Amaya and Bryan, 2015; Müller et al., 2016) OCT4 function in tumors is due to OCT4 / Tcl1 / Akt pathway. The gene discussed is KLF4; the disease is cancer.