We further examined additional measures of APOBEC activity in both tumor and virus and found similar trends for APOBEC RNA editing at the DDOST hairpin hotspot (p = 0.008), A3A mRNA expression (p = 0.14), and IFN-γ scores (p = 0.053), which are tied to APOBEC activity (Figure 3D–F). This evidence concerns the gene IFNG and neoplasm.