IL6 and macrophage activation syndrome: Moreover, as described in many studies, SARS-CoV-2 is able to activate in different ways the immune system; in particular, it can induce interleukin-6 (IL-6)-dependent pathways leading to cytokine storm and macrophage activation syndromes; in addition, it might alter interferon signalling in some cases [19,54,55,56,57,58].