UPRT and acute myeloid leukemia: In a study with acute myeloid leukemia (AML) cell lines and primary AML cells the oncolytic efficacy of a MeV construct armed with super cytosine deaminase (MeV-SCD), a yeast-derived CD-UPRT, which catalyzes the conversion of the inactive prodrug 5-FC into the therapeutically active and clinically approved compound 5-FU, was investigated.