Moreover, 11a (11 μmole/Kg) impeded CRC progression in C57BL/6 female mice xenografted human colon tumors by reducing VEGF mRNA expression (30%), GLUT1 mRNA expression (50%), vascularization (30%), and tumor size (90%) compared to OXA after 21 days [87]. This evidence concerns the gene SLC2A1 and colorectal carcinoma.