Some Ru-complexes including Ru(II) naphthalimide N-Heterocyclic Carbene compounds (3a), [Ru(piplartine)(1,1-bis(diphenylphosphino)ferrocene)(2,2′-bipyridine)](hexafluorophosphate)2 (3b), [Ru(piplartine)(1,4-bis(diphenylphosphino)butane)(2,2′-bipyridine)](hexafluorophosphate)2 (3c), and Ru(II)-thymine complex [Ru(triphenylphosphine)2(thyminate)(2,2′-bipyridine)]hexafluorophosphate (3d) (Figure 4) triggered apoptosis in CRC cells through MAPK (JNK, p38 MAPK, and ERK1/2) signaling pathway (Figure 3→III) [79,80,81]. This evidence concerns the gene MAPK8 and colorectal carcinoma.