TP53 and colorectal carcinoma: Ru-complexes including [Ru(η6-p-cym)(7-(4-(Decanoyl)piperazin-1-yl)-ciprofloxacin-H)Cl] (6a) and Ru-arene Schiff-base complexes particularly [(η6-1,3,5-triisopropylbenzene)RuCl(4-methoxy-N(2-quinolinylmethylene)aniline)]Cl (6b) (Figure 5) exhibited p53 independent anticancer property against CRC cells that are resistant to Pt-based anticancer drugs [116,117].