TLR4 and neoplasm: The other DAMP, HMGB-1 protein, residing in the nucleus moves to the extracellular space in the course of ICD and attach to pattern recognition receptors (PRRs) such as toll-like receptor 4 (TLR-4), receptor for advanced glycation end products (RAGE), and nuclear factor-κB (NF-κB) of DCs and presented antigens from dying tumor cells.