AKT1 and head and neck squamous cell carcinoma: PHT-427 (4-dodecyl-N-(5-(5-(methyl(7-nitrobenzo(c)(1,2,5)oxadiazol-4-yl)amino)pentyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide) binds to the PH domains of both AKT and PDPK1 and inhibits the activity of both proteins in pancreatic, prostate, ovarian, breast, and non-small cell lung cancer cells and in tumor xenografts of pancreatic cancer [11,12] but has never been tested in HNSCC.