These changes towards the overexpression of mesenchymal markers and downregulation of epithelial markers on GC-derived cell lines could also be explained by the higher ATP concentrations found at the extracellular level, which have been previously reported to induce the expression of EMT-related proteins like vimentin, Snail and Slug on the human non-small cell lung cancer cell line A549 [60]. Here, SNAI2 is linked to non-small cell lung carcinoma.