Apt–TNM-DOX specifically targeted CD30+ lymphoma cells (Karpas 299, SU-DHL-1, HDLM2, and KMH2), but did not react to off-target (CD30−) control cells (U937, Mino, HEL, and HL-60) (Figure 6A). This evidence concerns the gene TNFRSF8 and lymphoma.