ASGR1 and liver cancer: In vitro uptake studies of the cationic Ac-La-G(4)-PAMAM-FITC dendrimer (Ac = acetylated; La = Lactobionic acid) conducted by flow cytometry analysis and confocal laser scanning microscopic observations in the well differentiated human liver cancer cell line HepG-2, expressing the ASGP-R, and for comparison in HLE human liver cancer cells, characterized by undetectable level of receptor, confirmed the targeting specificity of Ac-La-G(4)-PAMAM-FITC dendrimer for ASGP-R expressing cells (Figure 5).