FOXP3 and encephalomyelitis: On the other hand, Riazifar et al. found that the intravenous administration of MSCs-EV stimulated by IFNγ reduced the mean clinical score of encephalomyelitis mice compared to PBS control, reduced demyelination, decreased neuroinflammation, and upregulated the number of CD4+CD25+FOXP3+ regulatory T cells (Tregs) within the spinal cords of encephalomyelitis mice [37].