Recently, 2-deoxy-d-glucose-modified poly(ethylene glycol)-co-poly(trimethylene carbonate) nanoparticles (DGlu-NP) loaded with paclitaxel were formulated as a drug delivery system to enhance the BBB penetration via GLUT-mediated transcytosis and improve the drug uptake in glioma via GLUT-mediated endocytosis. This evidence concerns the gene SLC2A1 and central nervous system cancer.