The targeting ability and anticancer efficacy of Sali-loaded polymer–lipid hybrid anti-HER2 nanoparticles was investigated against breast CSCs and cancer cells in a study conducted by Li et al. A nanoprecipitation method was employed to prepare the hybrid nanoparticles using PLGA, soybean lecithin and DSPE-PEG2000. This evidence concerns the gene ERBB2 and cancer.