CheckMate 9ER is a phase 3, randomized, open-label trial that evaluated the use of cabozantinib, an oral multi-kinase inhibitor with multiple targets (VEGFR2, c-MET, AXL, and RET), in combination with nivolumab in untreated advanced ccRCC patients. Here, KDR is linked to nonpapillary renal cell carcinoma.