However, control of the level and duration of the CDN expression by this approach can be a challenge since chronic STING activation has been involved and responsible for initiating certain inflammatory and autoimmune diseases due to type 1 IFN overproduction [4,156,157] In addition, sustained gene transcription is rigidly prevented by the host to avoid lethal STING-dependent proinflammatory disease by unknown mechanisms [158,159]. Here, STING1 is linked to autoimmune disease.