In this regard, cGAMP-induced STING activation promoted the polarization of tumour-associated macrophages into proinflammatory subtypes in spontaneous gastric cancer in p53(+/−) mice and cell line-based xenografts and induced apoptosis of gastric cancer cells through IL-6R-Janus kinase (JAK)-IL-24 pathway [88]. Here, TP53 is linked to gastric cancer.