CD274 and neoplasm: In this regard, a single dose of cGAMP-liposomal nanoparticles (cGAMP-NP) was sufficient to modulate the tumour microenvironment for effective control of programmed death-ligand 1 (PD-L1)-insensitive basal-like triple-negative breast cancer and melanoma and, more significantly, prevented the formation of secondary tumours in mice [82].