In this regard, cGAMP-induced STING activation promoted the polarization of tumour-associated macrophages into proinflammatory subtypes in spontaneous gastric cancer in p53(+/−) mice and cell line-based xenografts and induced apoptosis of gastric cancer cells through IL-6R-Janus kinase (JAK)-IL-24 pathway [88]. This evidence concerns the gene IL6R and gastric cancer.