CD47 and cancer: Furthermore, our anti-CD47 ADC could integrate multiple possible anti-cancer mechanisms: (1) direct TNBC cell death caused by the potent drug DM1, which has been used to treat other cancers via blocking of microtubulin polymerization; (2) increase of phagocytosis of CD47-positive TNBC cells (which needs further evaluation); and (3) potentially overcome the challenge of drug resistance in chemotherapy.