Although the potency of RBD-targeting nAbs against the D614G variant was not reduced, and antibodies stimulated by natural infection with SARS-CoV-2 containing D614 or G614 can be cross-neutralized, the conformational transfer induced by D614G towards ACE2 binding active states may still affect the effectiveness of some nAbs (e.g., type III nAbs that only bind closed RBDs) [50]. This evidence concerns the gene ACE2 and infection.