PSMD1 and infection: Numerous studies on SARS-CoV-2 and other pathogenic human CoVs such as MERS-CoV and SARS-CoV have dementated that most of the nAbs that are generated due to either natural infection or full-length S based vaccines target the S1 subunit, making S1 an attractive and probably safer immunogen for vaccine development [35,36,37,38,39].