Consistent with its role as a tumor suppressor, DKK-3 overexpression (by adenovirus-mediated transduction of an eukaryotic expression vector) represses tumor cell growth by inducing endoplasmic reticulum stress which in turn triggers JNK-dependent apoptosis and overexpression of IL-7 in cancer cells [52,53,54,55]. This evidence concerns the gene MAPK8 and neoplasm.