NPSR1 and psychiatric disorder: An important point to consider is that the findings from the experimental rodent models highlight the effects of the administration of NPS and NPSR1 antagonists in various brain regions on stress responses and reward-like and emotional behaviours (see summary in Table 1 and Table 3), whereas the majority of the clinical studies focused on the impact of the SNP rs324981 on behavioural and emotional changes in healthy individuals (see summary in Table 4 and Table 5), and only a few studies involved patients with a psychiatric disorder.