There are other agents targeting TGF-β signaling pathway, the antisense oligonucleotides Trabedersen (AP12009, Antisense Pharma GmbH/Isarna) targeting TGF-β2 expression has been studied in pancreatic cancer in a phase I clinical trial to evaluate safety and tolerability (NCT00844064). The gene discussed is TGFB1; the disease is pancreatic neoplasm.