TGFB1 and pancreatic neoplasm: BCA101 (Bicara Therapeutics) is an EGFR/TGF-β fusion mAb; it is studied in phase I alone or in combination with the anti-PD1 pembrolizumab in patients with EGFR-driven advanced solid tumors including pancreas cancer with KRAS G12D mutation (NCT04429542).