AFP and hepatocellular carcinoma: Therefore, the current study aims to (1) investigate the diagnostic efficacy of the biomarkers AFP, AFP-L3 and DCP for HCC detection, either alone, in combination or as part of the GALAD score, and (2) determine whether the GALAD score exhibits superior specificity compared to AFP, that frequently generates false-positive results in correlation to the virus related necroinflammation.