ADORA2A and obesity due to melanocortin 4 receptor deficiency: In addition, recent works have shown that A2Ar agonists, such as CGS21680 or PSB-0777, activate lipolysis, increase energy expenditure and oxygen consumption, improve glucose tolerance, protect from diet-induced obesity and, finally, induce browning of WAT, demonstrating adenosine A2A receptor involvement in browning process induction [20,21].