The main targeting sites in LC may include the overexpressed receptors on the surfaces of the cancer cells (e.g., epidermal growth factor receptor (EGFR), folate receptors (FRs), transferrin receptors (TfRs)), cellular organelles (e.g., mitochondria, lysosomes) and the LC microenvironment (e.g., vascular cell-adhesion molecules, cluster-of-differentiation 44, matrix-metalloproteases) [56]. The gene discussed is EGFR; the disease is cancer.