CRB1 and Leber congenital amaurosis: Presently, there are at least 15 LCA-associated genes, including CEP290, RPE65, CRB1, KCNJ13, GUCY2D, AIPL1, CRX, IMPDH1, LCA5, LRAT, RPGRIP1, SPATA7, RD3, RDH12, and TULP1. CEP290 mutant zebrafish displays an intracellular transport delay and a decreased visual perception, which is analogous to human LCA patients [131].