Moreover, OP inhibited the secretion of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-4 in RBL-2H3 cells (rat basophilic leukemia), possessing secretion concentrations of 100, 120, and 39 pg/mL, respectively; whereas DNP-HAS (dinitrophenyl-human serum albumin) was applied as a positive control, with secretion of 160, 240, and 55 pg/mL, respectively [28]. Here, TNF is linked to acute basophilic leukemia.