ACE and early-onset autosomal dominant Alzheimer disease: The health-promoting activities involved the inhibition of the key enzymes that control NCDs including lipase (obesity), α-amylase, and α-glucosidase (diabetes), angiotensin-converting enzyme (hypertension) and acetylcholinesterase, butyrylcholinesterase, and β-secretase (Alzheimer’s disease) as well as the non-enzymatic anti-glycation reaction (premature aging).