Causes of Alzheimer’s disease (AD), one type of dementia, have been attributed to (i) degradation of the neurotransmitter acetylcholine by acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), or (ii) accumulation of amyloid plaque formed during amyloidogenesis by β-secretase (BACE-1) [25]. This evidence concerns the gene BACE1 and Alzheimer disease.