ACHE and obesity due to melanocortin 4 receptor deficiency: Enzymes that are drug targets for NCDs include lipase (obesity), α-amylase and α-glucosidase (diabetes), angiotensin-converting enzyme (ACE) (hypertension) as well as acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and β-secretase (BACE-1) (AD).