PADI4 and cyst: In addition, studies have shown that chickpea CaRGA protein interacts with WRKY64 in the nucleus to positively regulate EDS1 transcription and cell death signaling [63]; furthermore, in studies of resistance to soybean cyst nematodes, the downstream signaling of PAD4 is involved in regulating the salicylate signaling pathway and, thus, positively regulates resistance to cyst nematodes [64].