Although it is clear that not only EBV LMP1 gene variability but also many other non-viral factors are involved in the etiopathogenesis of the NPC, the importance of identification of so-called “high-risk“ EBV variants could be crucial in defining relative variant tropism, designing targeted antiviral candidates or even make progress toward an EBV vaccine. The gene discussed is PDLIM7; the disease is nasopharyngeal carcinoma.