NLRP3 and HIV-associated neurocognitive disorder: The role of Tat in triggering microglial inflammation mediated by a Nod-Like Receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasomes is reported by in vitro findings and then confirmed in brain samples from SIV-infected macaques, demonstrating that pharmacological inhibition and genetic silencing of NLRP3 could reduce the neuroinflammation and the development of HAND [68].