While little is known about the role of LMP1 in the generation of CAFs in NPC [32], in this current study, we demonstrate a role for LMP1 in the recruitment of fibroblasts via an ERK-MAPK-dependent mechanism, with a partial contribution from TGFβ, enhanced fibroblast proliferation, and the subsequent transformation of fibroblasts to a myofibroblast-like phenotype in vitro. Here, PDLIM7 is linked to nasopharyngeal carcinoma.