As local infection is the preferred route for application of a vaccine in humans, we extend here on our previous work in the BALB/c mouse model with intraplantar infection [65,69] to compare the long-term development of CD8+ T-cell memory specific for the two most prominent MI-driving IDEs m123/IE1 and m164 with that specific for not MI-driving non-IDE m18 (Figure 1). This evidence concerns the gene CD8A and infection.