ADGRF5 and pulmonary emphysema: A putative Tc-MUC-3 interacting partner, adhesion G protein-coupled receptor F5 (ADGRF5 or GPR116), regulates pulmonary alveolar homeostasis and its knockout leads to an early accumulation of surfactant in the lungs of mice, followed by a massive infiltration of foamy alveolar macrophages, eventually progressing into an emphysema-like pathology [64,65].