Sprayed immunotherapeutic fibrin gel composed of fibrinogen and thrombin with CaCO3 nanoparticle to deliver aCD47 and control release in the acidic tumor microenvironment during six days in mouse animal model blocking the interaction of CD47 on cancer cells could enhance phagocytic cancer cells by macrophages, dendritic cells, and neutrophils [55]. Here, CD47 is linked to cancer.