SOCS3 and hepatocellular carcinoma: To investigate the effect of SOCS3 inhibition on HCC metastasis, we knocked down SOCS3expression with small interfering RNAs (siRNAs) in 7404 cells and confirmed the expressionlevels of SOCS3 in 7404 + control siRNA (siNC), 7404 + siSOCS3, and 7404-Bap100 cells(Figure 4A).