Several of these SNVs, rs3771501 (TGFA), rs3993110 (TEAD1/DKK3), rs72979233 (CHRDL2), and rs7967762 (PFKM/WNT10B) (Figures 2B and 2D), are associated with multiple osteoarthritis joint sites. Here, DKK3 is linked to osteoarthritis.