Augurin, the protein encoded by C2orf40 (also called ECRG4), is involved in CNS development in animal models (Gonzalez et al., 2011) and shows association with neuropathologic features of Alzheimer’s disease and related dementias in humans (Beecham et al., 2014). This evidence concerns the gene ECRG4 and early-onset autosomal dominant Alzheimer disease.