TNFSF11 encodes receptor activator of nuclear factor kappa-β ligand (also known as RANKL), a cytokine that has been linked to inflammatory bone remodeling in rheumatoid arthritis, with increased TNFSF11 levels associated with worsening arthritis severity (Papadaki et al., 2019; Remuzgo-Martínez et al., 2016) and a well-established role in osteoclastogenesis (Kohli and Kohli, 2011). This evidence concerns the gene TNFSF11 and arthritic joint disease.