Recent studies have concluded that although the naïve CD4 T-cell subset has a lower frequency of HIV infection compared with memory CD4 T-cell subsets, these cells harbor more replication competent HIV-1 than previously thought, and that could be a significant contributor to HIV persistence [72,73] In our study, intact provirus could not be assessed due to the limited number of purified cells obtained. This evidence concerns the gene CD4 and HIV infectious disease.