HCN3 and malaria: On the other hand, tests for recent selection (up to 25kya) identified a signature of an extended haplotype homozigosity in a PKLR/HCN3 region of eQTL SNPs for Europeans, but not for Africans (xpEHH test), where it was expected under the hypothesis of malaria-driven selection (see the summarized results in S9 Table).