Given the limited resources available for population screening efforts, and regular control for some key elements (viral load, CD4 count, ASAT, ALAT, albumin, bilirubin, creatinine), the present study was aimed to evaluate the treatment response of HIV patients and those co-infected with hepatitis B or C. It further sought to identify associated risk factors linked to the treatment outcome among these HIV-1 infected patients placed on HAART, which would contribute toward the understanding of the burden of the viral hepatitis co-infections and at-risk populations in Cameroon. The gene discussed is CD4; the disease is hepatitis B virus infection.