This event correlates with downregulation by the silencing of TG2-lncRNA in various genes, already known to be usually overexpressed in BrCa, such as PKD1, HSPB1, DVL1, SPHK2, HRAS, JAG2, NOTCH1, AKT1, PIK3R2, DVL2, PLD2, GRB7, PDGFB, AKT2, PRKCZ, FGFR1, RHOC, PXN, PIK3C2B, and PLCG1 [35,37,38,39,40,41,42,43,44,45,46,47,48,49,50]. This evidence concerns the gene SPHK2 and invasive breast carcinoma.