HOXA2 and Familial prostate cancer: Single nucleotide editing in combination with ChIP-seq (Chromatin Immunoprecipitation followed by Sequencing) experiments revealed that binding of HOXA2 positively regulates not only PCAT19 but also its neighboring locus CEACAM21. Thus, the interplay of rs11672691 with the regulatory circuit of HOXA2, PCAT19 and CEACAM21 is linked to advanced cell growth and invasion with a significant clinical impact on prostate cancer disease aggressiveness and severity, highlight the role of enhancer mutations in the regulation of neighboring coding and non-coding targets in cancer tissues [68,135].