Binding of miR-194-5p to the MALAT1 transcript with the rs664589-C genotype targets it for degradation in the nucleus, in contrast to the G allele that decreases overall binding affinity of the miRNA, leading to accumulation of MALAT1 and ultimately poor patient survival, increased distant metastasis and enhanced tumor growth (Figure 3D, [91]). This evidence concerns the gene MALAT1 and neoplasm.