The authors found that the curcumin-based gel could restore the normal distribution of TJs protein ZO1 and occludin, reduce the expression of TNF-α, and inducible nitric oxide synthase (iNOS), indicating that the curcumin-based supramolecular gel can improve the therapeutic effect of psoriasis and have a good application prospect. The gene discussed is NOS2; the disease is psoriasis.