CD68 and granular cell tumor: Morphology of lesions could be a great help in differential diagnosis involving comparisons with the benign granular cell tumor (GCT), which differs from granular cell dermatofibroma (GCDF) by the different histogenesis: in fact, an immunohistochemical study with antibodies against the S-100 protein is strongly and diffusely positive in benign granular cell tumor, but negative in GCDF, just as CD68 will be positive in GCDF and almost totally negative in GCT [7,8].