Although the current study might not clearly explain the disease-causing relationship between viral (EBV, HCMV, HSV) and periodontal bacterial (Pg, Pi, Tf, Td, Fn) co-infection in preeclampsia, it suggests the role of viral-bacterial interplay in the pathogenesis of preeclamptic pregnant women with chronic periodontitis. This evidence concerns the gene TF and preeclampsia.