Studies in macrophages, dendritic, T and B-cells have demonstrated the importance of GRP94/GP96 in the innate response against infection, improving the detection and signaling related to TLR2, TLR4 and TLR9; also, in the intensification of inflammatory response mediated by cytokines, early activation of T and B-cells, improvement in the B-cell functions and, combined with cochaperone proteins participates in the folding of immunoglobulins [44,45,46,47,48,49,50,51]. Here, TLR4 is linked to infection.